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Sure. I did it in the following order: uninstalled 6.4, intalled 6.5 from github(a few days before your official release), installed simplified economy/drops available to all protagonists(both I believe might be relevant) from IA tweaks. I didn't uninstall cdtweaks, could it be the 'allowing cromwell forging cespensar only items' conponent that lead to this problem?
Yes, it's either the component from cdtweaks or (less probable) not starting a new game with the 6.5, provided you've had one going already and has already visited Cromwell before installing 6.5 + simplified economy. But my bet is on the conflict between the two mods. Both of them modify the same conversation files, so there's bound to be some sort of a conflict, unfortunately.
I'm surprised that you didn't encounter any issues when you've had cdtweaks component + 6.4 installed. Everything was OK before installing 6.5?