SPOILER!
PArty= vagrant, jaheira, valygar, anomen, nalia, imoen, done all quests possible in chap 6 (apart orcus fight) plus 4 WK levels (still great wyrm and horde to complete on 5th floor), best weapons: hammer of thor, foa +4, root of the problem and staf of the ram (alas could not forge any of the two precious halberds due to missing components)
to make it short, on my first attempt I managed to kill every foe in twisted rune apart from layenne, and:
Vagrant (who was hidden from layenne los at the time) came in sight of layenne, she started to cast dispel magic, I retreated in the entrance so that other party members would not be touched, then her doudle timestop + alacrity fired while I was out of her sight, and she did nothing during timestop.
Afterwards, fight was a bit nasty (new summons, which kind I don't spoil), loads of spells but in the end she fell. Big self pride to win in my first attempt .
I retried the battle taking her blows on the chin (that is to say vagrant staying in her los), but whatever buffs, potions,... I took, she just obliterates my character at the end of double timestop.
Retried 6 times for same results
I have to confess that if my way of doing is cheesy, then I don't see how to win this fight with a non magic-user character