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I've come to a grinding halt in the first level of Kresselack's tomb.
SPOILERS
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I'm in the chamber with the two large pools of glowing fluid. I can't open the gate at the top of the stairs in the north of this room. I have searched all the other tombs and caves, and all the rooms off this main chamber as well. I've got these 3 keys - priest's key; gate key; sanctum key.